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Journal of Wood Science

Official Journal of the Japan Wood Research Society

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5α-Reductase inhibitory compounds produced by polymerization of resveratrol with horseradish peroxidase

Journal of Wood Science volume 48, pages 64–68 (2002)Cite this article

Abstract

To produce 5α-reductase inhibitory compounds, resveratrol was enzymatically oxidized in a horseradish peroxidase (HRP)/H2O2 system. Ethyl acetate extract of the oxidation products showed strong 5α-reductase inhibitory activity with 10%–15% organic solvents in the system, whereas without organic solvent little inhibitory activity was exhibited. The optimum pH of enzymatic oxidation for acquisition of the inhibitory activity was 4.5. The inhibitory compounds were isolated and identified as resveratroltrans-dehydrodimer and resveratrolcis-dehydrodimer by comparing with published nuclear magnetic resonance data. The two resveratrol dehydrodimers have stronger inhibitory activity than natural resveratrol dimers and trimers found inShorea species.

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Authors and Affiliations

  1. Interior Design Research Institute, Fukuoka Industrial Technology Center, Agemaki, 405-3, Okawa, 831-0031, Fukuoka, Japan

    Yoshio Hirano

  2. Department of Forest Products, Faculty of Agriculture, Kyushu University, 812-8581, Fukuoka, Japan

    Ryuichiro Kondo & Kokki Sakai

Authors
  1. Yoshio Hirano
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  2. Ryuichiro Kondo
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  3. Kokki Sakai
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Correspondence to Yoshio Hirano.

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Hirano, Y., Kondo, R. & Sakai, K. 5α-Reductase inhibitory compounds produced by polymerization of resveratrol with horseradish peroxidase. J Wood Sci 48, 64–68 (2002). https://doi.org/10.1007/BF00766240

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  • DOI: https://doi.org/10.1007/BF00766240

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