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Official Journal of the Japan Wood Research Society

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Compounds inhibitory to rat liver 5α-reductase from tropical commercial wood species: resveratrol trimers from melapi (Shorea sp.) heartwood

Abstract

5α-Reductase inhibitory activity of methanol extracts of the heartwood of 13 tropical wood species were examined. Strong 5α-reductase inhibitory activity was observed withShorea species. From melapi (Shorea sp.), two known resveratrol trimers, vaticanol A and ampelopsin C, and two novel trimers were isolated as active compounds. The structures of the two novel resveratrol trimers were elucidated by one- and two-dimensional nuclear magnetic resonance spectroscopic analyses, including1H-1HCOSY, HMQC, and HMBC. The compounds were named melapinol A and melapinol B. There were no significant differences among the 5α-reductase inhibitory activities of the four resveratrol trimers, which were significantly stronger than those ofα-linolenic acid and epigallocatechin gallate, known 5α-reductase inhibitors.

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Correspondence to Yoshio Hirano.

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Hirano, Y., Kondo, R. & Sakai, K. Compounds inhibitory to rat liver 5α-reductase from tropical commercial wood species: resveratrol trimers from melapi (Shorea sp.) heartwood. J Wood Sci 47, 308–312 (2001). https://doi.org/10.1007/BF00766718

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Key words

  • Melapi
  • Shorea species
  • Dipterocarpaceae
  • 5α-Reductase inhibitor
  • Resveratrol trimer