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Official Journal of the Japan Wood Research Society

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Proliferating effect of extracts from woods and fungi on rat vibrissa dermal papilla cells


Hair growth is a highly regulated cyclical process. Three distinct phases have been defined for the mammalian cycle: anagen (growing phase), catagen (regression phase), and telogen (resting phase). Although little is known about the mechanism that regulates the hair cycle, it is believed that dermal papillae (DP) derived from mesenchymal cells play an essential role in controlling the established hair follicle and hair cycle. The purpose of this investigation was to find the components of woods and fungi that exert a proliferative activity on DP cells. Results show that the fungus YL161 (ethyl acetate extract, 1ppm),Agaricus blazei (ethyl acetate extract, 0.1 ppm), and the bark ofCamptotheca cuminata (methanol extract of bark, 0.1 ppm) exhibit higher growth-promoting activity than pentadecanoic acid. These components that have a proliferative effect on DP cells may be useful hair growth-stimulating materials and can be used to understand the mechanism of hair growth.


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Correspondence to Ryuichiro Kondo.

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Towatari, K., Kondo, R. & Sakai, K. Proliferating effect of extracts from woods and fungi on rat vibrissa dermal papilla cells. J Wood Sci 47, 410–413 (2001).

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Key words

  • Dermal papilla
  • Hair cycle
  • Wood
  • Fungus