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5α-Reductase inhibitory component from leaves ofArtocarpus altilis

Abstract

The inhibitory effects of 17 samples prepared from Thailand plants on 5α-reductase activity were examined. The acetone extract of leaves ofArtocarpus altilis showed potent 5α-reductase inhibitory activity. Fractionation guided by 5α-reductase inhibition led to the isolation of 2-geranyl-2′,3,4,4′-tetrahydroxydihydrochalcone from the acetone extract of leaves ofA. altilis. This compound showed more potent inhibitory effect (IC50=38ΜM) thanα-linolenic acid known as a naturally occurring potent inhibitor.

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Correspondence to Ryuichiro Kondo.

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Shimizu, K., Kondo, R., Sakai, K. et al. 5α-Reductase inhibitory component from leaves ofArtocarpus altilis . J Wood Sci 46, 385–389 (2000). https://doi.org/10.1007/BF00776401

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Key words

  • Artocarpus altilis (Parkins) Fosberg
  • Moraceae
  • Leaves
  • 5α-Reductase inhibitor
  • 2-Geranyl-2′,3,4,4′-tetrahydroxydihydrochalcone