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Journal of Wood Science

Official Journal of the Japan Wood Research Society

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5α-Reductase inhibitory component from leaves ofArtocarpus altilis

Journal of Wood Science volume 46, pages 385–389 (2000)Cite this article

Abstract

The inhibitory effects of 17 samples prepared from Thailand plants on 5α-reductase activity were examined. The acetone extract of leaves ofArtocarpus altilis showed potent 5α-reductase inhibitory activity. Fractionation guided by 5α-reductase inhibition led to the isolation of 2-geranyl-2′,3,4,4′-tetrahydroxydihydrochalcone from the acetone extract of leaves ofA. altilis. This compound showed more potent inhibitory effect (IC50=38ΜM) thanα-linolenic acid known as a naturally occurring potent inhibitor.

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Authors and Affiliations

  1. Department of Forest Products, Faculty of Agriculture, Kyushu University, 812-8581, Fukuoka, Japan

    Kuniyoshi Shimizu, Ryuichiro Kondo & Kokki Sakai

  2. Kasetsart Agriculture and Agro-Industrial Product Improvement Institute, Kasetsart University, Bangkok, Thailand

    Supanida Buabarn & Uraiwan Dilokkunanant

Authors
  1. Kuniyoshi Shimizu
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  2. Ryuichiro Kondo
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  3. Kokki Sakai
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  4. Supanida Buabarn
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  5. Uraiwan Dilokkunanant
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Correspondence to Ryuichiro Kondo.

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Shimizu, K., Kondo, R., Sakai, K. et al. 5α-Reductase inhibitory component from leaves ofArtocarpus altilis . J Wood Sci 46, 385–389 (2000). https://doi.org/10.1007/BF00776401

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  • DOI: https://doi.org/10.1007/BF00776401

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