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Journal of Wood Science

Official Journal of the Japan Wood Research Society

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Indole-3-carbaldehyde: a tyrosinase inhibitor from fungus YL185

Journal of Wood Science volume 49, pages 349–354 (2003)Cite this article

Abstract

Indole-3-carbaldehyde (1) was isolated as a tyrosinase inhibitor from the ethyl acetate-soluble fraction of extracellular fluids of unknown fungus YL185. The partial sequencing data of 18S ribosomal DNA (18S rDNA) indicate that this isolate belongs to the family Polyporaceae or Corticiaceae sensu lato. Indole-3-carbaldehyde inhibited the oxidation of l-3,4-dihydroxyphenylalanine (l-DOPA) by mushroom tyrosinase with a 50% inhibitory concentration (IC50) of 1.3 mM and showed inhibitory activity on melanin production in B16 melanoma cells. The aldehyde group of 1 plays an important role in eliciting tyrosinase inhibitory activity.

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Authors and Affiliations

  1. Department of Forest and Forest Products Sciences, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581, Japan

    Kuniyoshi Shimizu, Xinglian Geng, Mika Hashiguchi, Hiroto Suhara, Syoko Fukunaga, Seiji Yasutake & Ryuichiro Kondo

  2. Chisso Corporation, Yokohama, 236-8605, Japan

    Mototake Tsutsui & Ikuo Sato

Authors
  1. Kuniyoshi Shimizu
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  2. Xinglian Geng
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  3. Mika Hashiguchi
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  4. Hiroto Suhara
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  5. Syoko Fukunaga
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  6. Seiji Yasutake
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  7. Ryuichiro Kondo
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  8. Mototake Tsutsui
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  9. Ikuo Sato
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Shimizu, K., Geng, X., Hashiguchi, M. et al. Indole-3-carbaldehyde: a tyrosinase inhibitor from fungus YL185. J Wood Sci 49, 349–354 (2003). https://doi.org/10.1007/s10086-002-0484-8

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  • DOI: https://doi.org/10.1007/s10086-002-0484-8

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