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Official Journal of the Japan Wood Research Society

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Screening of Indonesian plants for tyrosinase inhibitory activity

Journal of Wood Science volume 51, pages 520–525 (2005)Cite this article

Abstract

In our efforts to find new tyrosinase inhibitory materials, we investigated 44 Indonesian plants belonging to 24 families for tyrosinase inhibitory activity. The extracts of 5 Artocarpus woods showed potent tyrosinase inhibitory activity (over 80% at 100 µg/ml) similar to a positive control, kojic acid. In Artocarpus woods, the extracts of the sapwoods showed stronger inhibitory activity than those of the heartwoods. Chlorophorin was isolated as one of the active compounds in the sapwood of Artocarpus heterophyllus. The content of chlorophorin in sapwood was higher than that in heartwood.

References

  1. A Sánchez-Ferrer JN Rodrígez-López F García-Carmona (1995) ArticleTitleTyrosinase: a comprehensive review of its mechanism Biochim Biophys Acta 1247 1–11

    Google Scholar 

  2. J Cabanes S Chazarra F García-Carmona (1994) ArticleTitleKojic acid, a cosmetic skin whitening agent, is a slow-binding inhibitor of catecholase activity of tyrosinase J Pharm Pharmacol 46 982–985

    Google Scholar 

  3. C Murray R D'Intino R MacCormick B Nassar N Walsch (1999) ArticleTitleMelanosis in association with metastatic malignant melanoma: report of a case and a unifying concept of pathogenesis Am J Dermatopath 241 28–30

    Google Scholar 

  4. TJ Brown BR Nelson (1999) ArticleTitleMalignant melanoma: a clinical review Cutis 63 275–278

    Google Scholar 

  5. KJ Kramer MR Kanost TL Hopkins H Jiang YC Zhu R Xu JL Kerwin F Turecek (2001) ArticleTitleOxidative conjugation of catechols with proteins in insect skeletal systems Tetrahedron 57 385–392

    Google Scholar 

  6. Kubo I (1997) Tyrosinase inhibitors from plants. In: Phytoche-micals for pest control. ACS symposium series, vol 658, pp 310–326

  7. AJ McEvily R Iyneger WS Otwell (1992) ArticleTitleInhibition of enzymatic browning in foods and beverages Crit Rev Food Sci Nutr 32 253–273

    Google Scholar 

  8. Y Xu AH Stokes WM Freeman SC Kumer BA Vogt KE Vrana (1997) ArticleTitleTyrosinase mRNA is expressed in human substantia nigra Mol Brain Res 45 159–162

    Google Scholar 

  9. K Maeda M Fukuda (1996) ArticleTitleArbutin: mechanism of its depigmenting action in human melanocyte culture J Pharmacol Exp Ther 276 765–769

    Google Scholar 

  10. H Shimogaki Y Tanaka H Tamai M Masuda (2000) ArticleTitleIn vitro and in vivo evaluation of ellagic acid on melanogenesis inhibition Int J Cosmet Sci 22 291–303

    Google Scholar 

  11. YM Kim J Yun C-K Lee H Lee KR Min Y Kim (2002) ArticleTitleOxyresveratrol and hydroxystilbene compounds. Inhibitory effect on tyrosinase and mechanism of action J Biol Chem 277 16340–16344

    Google Scholar 

  12. K Shimizu R Kondo K Sakai S-H Lee H Sato (1998) ArticleTitleThe inhibitory components from Artocarpus incisus on melanin biosynthesis Planta Med 64 408–412

    Google Scholar 

  13. RS Soedarsono SR Harini (2002) ArticleTitleJamu as traditional medicine in Java, Indonesia South Pacific Study 23 1–9

    Google Scholar 

  14. CA Pilotti R Kondo K Shimizu K Sakai (1995) ArticleTitleAn examination of the anti-fungal components in the heartwood extracts of Pterocarpus indicus (in Japanese) Mokuzai Gakkaishi 41 593–597

    Google Scholar 

  15. K Shimizu R Kondo K Sakai N Takeda T Nagahata (2002) ArticleTitleThe skin-lightening effects of artocarpin on UVB-induced pigmentation Planta Med 68 79–81

    Google Scholar 

  16. K Shimizu M Fukuda R Kondo K Sakai (2000) ArticleTitleThe 5S61537-reductase inhibitory components from heartwood of Artocarpus incisus: structure-activity investigations Planta Med 66 16–19

    Google Scholar 

  17. M Kumar WH Flurkey (1991) ArticleTitleActivity, isoenzymes, and purity of mushroom tyrosinase in commercial preparations Phytochemistry 30 3899–3902

    Google Scholar 

  18. I Kubo I Kinst-Hori SK Chaudhuri Y Kubo Y Sánchez T Ogura (2000) ArticleTitleFlavonols from Heterotheca inuloides: tyrosinase inhibitory activity and structural criteria Bioorg Med Chem 8 1749–1755

    Google Scholar 

  19. K Likhitwitayawuid B Sritularak (2001) ArticleTitleA new dimeric with tyrosinase inhibitory activity from Artocarpus gomezianus J Nat Prod 64 1457–1459

    Google Scholar 

  20. YM Syah SA Achmad EL Ghisalberti EH Hakim L Makmur D Mujahidin (2001) ArticleTitleArtoindonesianins G-I, three new isoprenylated flavones from Artocarpus lanceifolius Fitoterapia 72 765–773

    Google Scholar 

  21. EH Hakim Yurnawilis Asnizar N Aimi M Kitajima H Takayama (2002) ArticleTitleArtoindonesianin P, a new prenylated flavone with cytotoxic activity from Artocarpus lanceifolius Fitoterapia 73 668–673

    Google Scholar 

  22. HM Cidade MS Nacimento MM Pinto A Kijjoa AM Silva W Herz (2001) ArticleTitleArtelastocarpin and carpelastofuran, two new flavones, and cytotoxicities of prenyl flavonoids from Artocarpuse elasticus against three cancer cell lines Planta Med 67 867–870

    Google Scholar 

  23. C Boonlaksiri W Oonanant P Kongsaeree P Kittakoop M Tanticharoen Y Thebtaranonth (2000) ArticleTitleAn antimalarial stilbene from Artocarpus integer Phytochemistry 54 415–417

    Google Scholar 

  24. T Nomura Y Hano M Aida (1998) ArticleTitleIsoprenoid-substituted flavonoids from Artocarpus plants (Moraceae) Heterocycles 47 1179–1205

    Google Scholar 

  25. MR Khan AD Omoloso M Kihara (2003) ArticleTitleAntibacterial activity of Artocarpus heterophyllus Fitoterapia 74 501–505

    Google Scholar 

  26. T Fukai K Satoh T Nomura H Sakagami (2003) ArticleTitleAntinepheritis and radical scavenging activity of prenylflavonoids Fitoterapia 74 720–724

    Google Scholar 

  27. AD Patil AJ Freyer L Killmer P Offen PB Taylor BJ Votta RK Johnson (2002) ArticleTitleA new dimeric dihydrochalcone and a new prenylated flavone from the bud covers of Artocarpus altilis: potent inhibitors of cathepsin K J Nat Prod 65 624–627

    Google Scholar 

  28. BN Su M Cuendet ME Hawthorne LBS Kardono S Riswan HHS Fong RG Mehta JM Pezzuto AD Kinghorn (2002) ArticleTitleConstituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity J Nat Prod 65 163–169

    Google Scholar 

  29. F Cerqueira A Cordiero-Da-Silva N Araujo H Cidade A Kijjoa MSJ Nascimento (2003) ArticleTitleInhibiton of lymphocyte by prenylated flavones: artelastin as a potent inhibitor Life Sci 73 2321–2334

    Google Scholar 

  30. JC Espin R Varon LG Fenoll MA Gilabert PA García-Ruiz J Tudela F Garcia-Canovas (2000) ArticleTitleKinetic characterization of the substrate specificity and mechanism of mushroom tyrosinase Eur J Biochem 267 1270–1279

    Google Scholar 

  31. JY Lim K Ishiguro I Kubo (1999) ArticleTitleTyrosinase inhibitory p-coumaric acid from Ginseng leaves Phytother Res 13 371–375

    Google Scholar 

  32. M Jimenez S Chazarra J Escribano J Cabanes F Garcia-Carmona (2001) ArticleTitleCompetitive inhibition of mushroom tyrosinase by 4-substituted benzaldehydes J Agric Food Chem 49 4060–4063

    Google Scholar 

  33. S Takahashi (1988) JAMU Hirayama-Shuppan-Sha Tokyo 166

    Google Scholar 

  34. K Venkataraman (1972) ArticleTitleWood phenolics in the chemotaxonomy of the Moraceae Phytochemistry 11 1571–1586

    Google Scholar 

  35. K Shimizu R Kondo K Sakai (2000) ArticleTitleInhibition of tyrosinase by flavonoids, stilbenes and related 4-substituted resorcinols: structure-activity investigations Planta Med 66 11–15

    Google Scholar 

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Authors and Affiliations

  1. Systematic Forest and Forest Products, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581, Japan

    Enos Tangke Arung, Irawan Wijaya Kusuma, Seiji Yasutake, Kuniyoshi Shimizu & Ryuichiro Kondo

  2. Indonesian Institute of Sciences, Research Center for Chemistry, Serpong, 15314, Indonesia

    Yetti Mulyati Iskandar

Authors
  1. Enos Tangke Arung
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  2. Irawan Wijaya Kusuma
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  3. Yetti Mulyati Iskandar
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  4. Seiji Yasutake
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  5. Kuniyoshi Shimizu
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  6. Ryuichiro Kondo
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Corresponding author

Correspondence to Ryuichiro Kondo.

Additional information

Part of this paper was presented at the 53rd (Fukuoka, March 2003) and 54th (Hokkaido, August 2004) Annual Meetings of the Japan Wood Research Society, and the 5th International Wood Science Symposium (Kyoto, September 2004)

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Arung, E., Kusuma, I., Iskandar, Y. et al. Screening of Indonesian plants for tyrosinase inhibitory activity. J Wood Sci 51, 520–525 (2005). https://doi.org/10.1007/s10086-004-0690-7

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  • DOI: https://doi.org/10.1007/s10086-004-0690-7

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