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Synthesis of β-O-4 type oligomeric lignin model compound by the nucleophilic addition of carbanion to the aldehyde group
Journal of Wood Science volume 52, pages 255–260 (2006)
Abstract
A synthetic method for obtaining lignin oligomer that contains only the β-O-4 structure is described in detail. This method consists of three reaction steps: (1) the synthesis of t-butoxycarbonylmethyl vanillin (2), (2) the nucleophilic addition oligomerization of compound 2, and (3) the reduction of the oligomeric β-hydroxyl ester. In the first step, compound 2 was synthesized from vanillin in 96.8% yield. In the second step, compound 2 was oligomerized with commercial lithium diisopropylamide (LDA) to obtain oligomeric β-hydroxyl ester (3) in 87.2% yield; the repeating units of this oligomer were joined only by β-O-4 linkages as confirmed by nuclear magnetic resonance (NMR) spectroscopy. In the third step, the oligomeric β-hydroxyl ester (3) was reduced with LiAlH4 to give compound 4 in 42.4% yield. On the basis of NMR, matrix-assisted laser desorption ionization time-of-flight mass spectrometry, and gel permeation chromatography analyses of compound 4, it was concluded that compound 4 was an oligomeric lignin model compound containing only β-O-4 interunit linkages. The number average degree of polymerization (DPn) of obtained compound 4 was about 7.0 (M w/M n = 1.42). Using this oligomeric lignin model compound, conventional degradation and analytical methods will give new information.
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Katahira, R., Kamitakahara, H., Takano, T. et al. Synthesis of β-O-4 type oligomeric lignin model compound by the nucleophilic addition of carbanion to the aldehyde group. J Wood Sci 52, 255–260 (2006). https://doi.org/10.1007/s10086-005-0756-1
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DOI: https://doi.org/10.1007/s10086-005-0756-1