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Official Journal of the Japan Wood Research Society

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Steroid 5α-reductase inhibitory activity of condensed tannins from woody plants

Journal of Wood Science volume 54, pages 68–75 (2008)Cite this article

Abstract

In humans, steroid 5α-reductase is involved in the development of benign prostatic hyperplasia (BPH). We tested the steroid 5α-reductase inhibitory activity of the 70% acetone extract of woody plants. The tannin polymer prepared from the 70% acetone extract showed the highest steroid 5α-reductase inhibitory activity. Furthermore, the steroid 5α-reductase inhibitory activity of tannins was not affected by the addition of superoxide dismutase or catalase. It was concluded that the steroid 5α-reductase inhibitory activity of condensed tannin was caused by binding to the steroid 5α-reductase, rather than from the peroxide/superoxide produced by tannins. The tannins, prepared from tree barks, with potential for steroid 5α-reductase inhibitory activity might be advantageous in therapy for steroid 5α-reductase diseases such as BPH or prostate cancer.

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Authors and Affiliations

  1. Department of Forest and Forest Products Science, Faculty of Agriculture, Kyushu University, Fukuoka, 812-8581, Japan

    Jie Liu, Ryo Ando, Kuniyoshi Shimizu & Ryuichiro Kondo

  2. Forestry and Forest Products Research Institute, Tsukuba, 305-8687, Japan

    Koh Hashida, Rei Makino & Seiji Ohara

Authors
  1. Jie Liu
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  2. Ryo Ando
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  3. Kuniyoshi Shimizu
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  4. Koh Hashida
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  5. Rei Makino
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  6. Seiji Ohara
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  7. Ryuichiro Kondo
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Correspondence to Ryuichiro Kondo.

Additional information

Part of this report was presented at the 54th Annual Meeting of the Japan Wood Research Society, Sapporo, August 2004

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Liu, J., Ando, R., Shimizu, K. et al. Steroid 5α-reductase inhibitory activity of condensed tannins from woody plants. J Wood Sci 54, 68–75 (2008). https://doi.org/10.1007/s10086-007-0905-9

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  • DOI: https://doi.org/10.1007/s10086-007-0905-9

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