A glucosylceramide with antimicrobial activity from the edible mushroom Pleurotus citrinopileatus

Journal of Wood Science

Official Journal of the Japan Wood Research Society

Table 1 Biological activity of compound 1 from methanol extract, the fruiting bodies of P. citrinopileatus

Test samples	Antimicrobial activity [IC₅₀ (µM)]		Antioxidant activity (%)			Effect in B16 melanoma cells		Hyaluronidase inhibition (%)
Test samples	S. aureus	E. coli	ORAC	DPPH	SOD	MC (%)	CV (%)	Hyaluronidase inhibition (%)
Compound 1	323.2	275.1	No activity	0.7 ± 0.5	9.4 ± 4.4	100.1 ± 5.9	98.2 ± 6.5	4.7 ± 1.7^a
Sorbic acid^b	1560.0	1516.1
Arbutin^c						70.3 ± 4.1	99.0 ± 5.3
Cromolyn sodium salt^d								44.2 ± 5.7

Data presented as means ± SD (n = 3)
S. aureus, Staphylococcus aureus; E. coli, Escherichia coli; ORAC, oxygen radical absorbance capacity at 1595.6 µM; DPPH, 1,1-diphenyl-2-picrylhydrazyl radical scavenging at 724.8 µM; SOD, superoxide dismutase at 852.8 µM; MC, melanin content (%); CV, cell viability (%)
^aCompound 1 at 433.3 (µM)
^bPositive control of antibacterial activity
^cPositive control of melanin inhibition activity at 367.3 µM
^dPositive control of hyaluronidase activity at 936.9 µM