Effect of quercetin derivatives on melanogenesis stimulation of melanoma cells

Mitsunaga, Tohru; Yamauchi, Kosei

doi:10.1007/s10086-015-1476-9

Journal of Wood Science

Official Journal of the Japan Wood Research Society

Table 1 Intra- and extracellular melanogenesis activity and cell viability in B16 melanoma cells by the synthesized quercetin glycosides 1–11

From: Effect of quercetin derivatives on melanogenesis stimulation of melanoma cells

	Cell viability and melanogenesis activity (%)
	200 μM	100 μM	10 μM
1
Intercellular melanogenesis activity	190.5 ± 10.2*	151.5 ± 8.1*	137.0 ± 0.8*
Extracellular melanogenesis activity	125.5 ± 9.3	116.0 ± 12.6	99.7 ± 21.7
Cell viability	74.8 ± 2.1	86.8 ± 2.0	90.0 ± 6.9
3
Intercellular melanogenesis activity	206.9 ± 2.3**	157.1 ± 8.6*	116.3 ± 1.3
Extracellular melanogenesis activity	86.1 ± 2.7	85.1 ± 1.7	91.0 ± 4.1
Cell viability	68.4 ± 6.9*	80.9 ± 5.5	105.0 ± 3.8
4
Intercellular melanogenesis activity	176.0 ± 9.1*	126.8 ± 9.1*	102.6 ± 2.9
Extracellular melanogenesis activity	85.2 ± 4.9	91.0 ± 6.3	83.3 ± 5.8
Cell viability	81.1 ± 3.0	93.2 ± 0.6	99.6 ± 1.5
5
Intercellular melanogenesis activity	119.0 ± 7.4	78.9 ± 6.0	91.1 ± 5.5
Extracellular melanogenesis activity	93.3 ± 6.4	105.8 ± 3.3	102.4 ± 2.8
Cell viability	98.7 ± 12.4	112.6 ± 2.6	95.1 ± 1.6
6
Intercellular melanogenesis activity	99.7 ± 1.8	84.77 ± 2.1	79.7 ± 4.2
Extracellular melanogenesis activity	80.9 ± 3.8	92.3 ± 2.7	91.2 ± 2.0
Cell viability	99.7 ± 1.8	106.0 ± 8.3	106.8 ± 3.4
7
Intercellular melanogenesis activity	102.6 ± 15.5	97.8 ± 7.2	80.3 ± 2.14
Extracellular melanogenesis activity	96.9 ± 5.4	102.1 ± 0.6	93.0 ± 1.2
Cell viability	95.2 ± 0.4	93.9 ± 7.6	105.3 ± 0.7
8
Intercellular melanogenesis activity	92.6 ± 0.0	90.4 ± 15.1	89.7 ± 11.9
Extracellular melanogenesis activity	103.2 ± 11.7	95.0 ± 2.3	100.0 ± 3.5
Cell viability	77.4 ± 10.4	104.1 ± 3.5	107.3 ± 6.5
9
Intercellular melanogenesis activity	86.5 ± 9.1	113.9 ± 14.4	85.0 ± 1.5
Extracellular melanogenesis activity	74.6 ± 9.3	113.7 ± 0.5	103.2 ± 0.1
Cell viability	114.4 ± 4.8	78.0 ± 1.3	97.7 ± 2.5
10
Intercellular melanognenesis activity	96.3 ± 0.9	90.9 ± 13.3	96.8 ± 7.6
Extracellular melanogenesis activity	87.3 ± 12.6	95.1 ± 5.8	99.9 ± 3.8
Cell viability	105.6 ± 6.4	107.0 ± 2.6	97.8 ± 8.9
11
Intercellular melanogenesis activity	83.8 ± 1.9	78.9 ± 6.0	91.1 ± 5.5
Extracellular melanogenesis activity	91.9 ± 18.0	90.1 ± 2.1	104.5 ± 7.1
Cell viability	111.0 ± 9.6	112.6 ± 2.6	95.1 ± 1.6

Theophyline	500 μM	250 μM	125 μM
Intercellular melanogenesis activity	166.8 ± 31.7*	131.7 ± 1.9	127.6 ± 6.6
Extracellular melanogenesis activity	204 ± 1.6**	183.2 ± 3.2**	170.7 ± 0.7**
Cell viability	91.4 ± 1.3	94.4 ± 4.1	95.5 ± 11.0

Data are expressed as means ± SD (n = 2)
* p ≤ 0.05 and ** p ≤ 0.01 compared with respective control values

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