Table 2 Intra- and extracellular melanogenesis activity and cell viability in B16 melanoma cells by the synthesized quercetin derivatives 12–20

12

 Intercellular melanogenesis activity

157.3 ± 8.4*

–

 Extracellular melanogenesis activity

224.9 ± 18.2*

–

 Cell viability

74.4 ± 3.8

–

13

 Intercellular melanogenesis activity

–

132.3 ± 8.1*

 Extracellular melanogenesis activity

–

229.5 ± 17.6*

 Cell viability

–

75.6 ± 2.9**

14

 Intercellular melanogenesis activity

–

134.0 ± 4.3*

 Extracellular melanogenesis activity

–

222.8 ± 12.8**

 Cell viability

–

80.4 ± 0.5**

15

 Intercellular melanogenesis activity

–

127.7 ± 4.3*

 Extracellular melanogenesis activity

–

225.5 ± 10.8**

 Cell viability

–

95.3 ± 1.8

16

 Intercellular melanogenesis activity

–

125.6 ± 5.7

 Extracellular melanogenesis activity

–

97.5 ± 2.2

 Cell viability

–

103.6 ± 3.6

17

 Intercellular melanogenesis activity

–

102.4 ± 12.0

 Extracellular melanogenesis activity

–

105.5 ± 1.4

 Cell viability

–

92.7 ± 0.5

18

 Intercellular melanogenesis activity

–

110.2 ± 2.5

 Extracellular melanogenesis activity

–

100.5 ± 0.5

 Cell viability

–

99.7 ± 1.2

19

 Intercellular melanogenesis activity

104.6 ± 3.1

–

 Extracellular melanogenesis activity

126.6 ± 2.3

–

 Cell viability

110.0 ± 7.9

–

20

 Intercellular melanogenesis activity

148.4 ± 1.4**

–

 Extracellular melanogenesis activity

96.1 ± 1.8

–

 Cell viability

103.7 ± 1.1

–

Intercellular melanogenesis activity

166.8 ± 31.7*

Extracellular melanogenesis activity

204.0 ± 1.6**

Cell viability

91.4 ± 1.3